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Peer reviewed
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杨润祥 任宏轩 庄莉 董超 杨冠勤
Zhongliu fangzhi yanjiu, 2009 10Journal Article
目的观察表阿霉素微量泵入与静脉滴注的不良反应。方法将病理确诊的46例乳腺癌和19例淋巴瘤患者随机分成两组,微量泵入组31例,静脉滴注组34例,表阿霉素剂量为70mg/m2;每周期治疗前后检测血常规、心肌酶、心电图和口腔黏膜,以观察两种不同给药方法对患者骨髓、心脏和口腔黏膜的影响。结果微量泵入组第9~13天白细胞下降至最低,Ⅳ度骨髓抑制率为22.5%;静脉滴注组第7~9天白细胞下降至最低,Ⅳ度骨髓抑制率为8.8%;两组间比较差异有统计学意义。心肌酶在两组中化疗后较化疗前升高,静脉滴注组差异有统计学意义,但无临床意义;微量泵入组化疗前后差异既无统计学意义,也无临床意义。心电图在微量泵入组中化疗四周期后80%出现ST-T改变;静脉滴注组中化疗三周期后90%出现ST-T改变,其中20%(7/34)在静脉滴注过程中出现心悸、胸闷、心前区不适、心率增快(10~20)次/分。口腔黏膜炎在微量泵入组4人出现,占12.9%(4/31),静脉滴注组1人出现2.9%(1/34)。结论表阿霉素微量泵入能减轻心脏的毒性,但骨髓抑制出现时间后移,Ⅳ度骨髓抑制率及口腔黏膜炎发生率升高。
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