There is an active demand for full-color fluorophores in the field of fluorescent dyes. However, a core skeleton with a simple structure and easy modification is currently insufficient. Herein, we develop a range of full-color-tunable fluorophores 3a-3m based on the fluorinated benzothiadiazole skeleton and their control compounds 3n-3p . By regulating the charge transfer strength between donors and acceptors, the emission colors of 3a-3p spanning from blue to red ( λ em = 445-672 nm) are achieved. Interestingly, compounds 3a-3p with a fluorinated core skeleton exhibit sensitive solvatochromism effects, large Stokes shifts and excellent dual-state emission (especially 3c-3k ). Meanwhile, with the control of different substituents in the donor structure, ACQgens ( 3a-3i and 3n-3p ) can be facilely tuned to AIEEgens ( 3j-3m ). Notably, red AIEEgen 3m shows great potential for bioimaging in live cells with low cytotoxicity. By modulating donor and acceptor units, serial fluorinated benzothiadiazole-based full-color fluorophores with various luminescence properties, such as DSE, ACQ and AIEE effects, are developed. Importantly, red emitter 3m can be used in bioimaging.