E-resources
Open access
-
Nimmy Varghese, Sr; Ann Francis, Geetha; Muralidharan, Vidya; Idiculla, Jyothi
International journal of advanced research (Indore), 11/2022, Volume: 10, Issue: 11Journal Article
Objectives: The objective of this study was to estimate the occurrence of Vitamin B12 deficiency in patients with type 2 diabetes mellitus treated with metformin, and the clinical and biochemical profile of vitamin B12 deficiency in them. Materials and Methods: This was a cross sectional study. Type 2 Diabetics over the age of 18 years were recruited for the study. Patients were divided into two groups - one groupof 62 patients who were on metformin for more than 6 months and the other group of 62 patients who were on other oral hypoglycemic agents or insulin. Patients were interviewed using a questionnaire. Relevant blood investigations were done. Results: The mean (+SD) age of study population was 57 (±9.8) years with an age range of 35 to 79 years. There was high prevalence of vitamin B12 deficiency in patients with type 2 diabetic mellitus treated with metformin (22.6%)(p-value<0.001). This study showed a statistically significant inverse relationship between duration of metformin use and vitamin B12 levels (p-value 0.01). There was a statistically significant correlation between the dose of metformin and vitamin B12 deficiency – the higher the dose, the lower the average vitamin B12 level (p-value 0.02). The study revealed significantly increased neuropathic symptoms in Type 2 Diabetic patients on metformin with B12 deficiency than with normal B12 levels (p-value<0.001). Conclusions: This study demonstrated a high prevalence of vitamin B12 deficiency in patients with type 2 diabetic patients treated with metformin (22.6%). Hencethe measurement of vitamin B12 should become an essential part of the annual review in all patients with type 2 diabetic patients on metformin therapy. The study revealed significantly increased neuropathic symptoms in Type 2 Diabetic patients on metformin with B12 deficiency than with normal B12 levels.
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.