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Nielsen, Jens
Natural product reports, 09/2019, Volume: 36, Issue: 9Journal Article
Natural product biosynthesis is inherently linked with the primary metabolism in terms of providing precursors and co-factors. Thus, even though it is important to improve the performance of natural product biosynthetic enzymes in building efficient cell factories, it is equally important to engineer the central carbon metabolism, such that this is adjusted to meet the biosynthetic demand of the desired product. Natural product biosynthesis is inherently linked with the primary metabolism in terms of providing precursors and co-factors.
