The study aimed to assess the impact of an American ginseng nutritional product on relieving muscle fatigue post-Wushu Sanda exercise. Twenty Sanda athletes were randomly assigned to groups A and B for a 30-day Wushu Sanda training. Each participant was administered three capsules twice daily, either American ginseng and Acanthopanax senticosus or a placebo. Body composition, ratings of perceived exertion, and blood biochemical values were compared. No significant disparities in body composition and ratings of perceived exertion were observed between group A and group B before or after the experiment. However, the increase in ratings of perceived exertion for group A was slightly less pronounced compared to that of group B. On the first day of the experiment, no significant differences were observed in glucose, blood lactic acid, blood urea nitrogen, and creatine kinase between the two groups (P > 0.05). On the 15th and 30th days of the experiment, blood glucose levels were significantly higher in group A, while levels of creatine kinase, blood lactic acid, and blood urea nitrogen were lower, with statistically significant variances observed (P < 0.05). The American ginseng nutritional product can effectively alleviate muscle fatigue post-Wushu Sanda exercise and can be considered a nutritional supplement in sports training.