E-resources
Peer reviewed
-
Liang Liang Chi, Liang Liang Chi; Zhi Qiang Cai, Zhi Qiang Cai; Bo Wang, Bo Wang; Wei Tao Qin, Wei Tao Qin; Ya Nan Wang, Ya Nan Wang; Qiao Qiao Feng and Wen Jie Ren, Qiao Qiao Feng and Wen Jie Ren
Journal of the Chemical Society of Pakistan, 12/2023, Volume: 45, Issue: 6Journal Article
A series of 4-aminoquinazoline derivatives were designed and synthesized as epidermal growth factor receptor (EGFR) inhibitors in our group. The bioassay results showed all the target compounds possessed potential anti-tumor activities against on A549 and H1975 cell lines. The IC50 values of 8.35 (for A549) and 19.18 μM (for H1975) exhibited remarkable inhibitory activity of compound 7d, which were better compared to the positive control Afatinib (IC50 = 10.41 μM for A549, IC50 = 24.96 μM for H1975). In addition, the molecular docking and ADME prediction of compound 7d was carried out. The experimental results show the compound 7d is worth to further research and discuss.
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.