Mixedwood stands are composed of hardwoods and softwoods, with neither comprising greater than 75%-80% of basal area or aboveground biomass. By conferring associational resistance and greater resilience to forests when stressed or disturbed, the more diverse composition of mixedwood stands contributes to forest health. We analyzed three examples where mixedwood stands are more resistant to insect infestations in eastern North America. In balsam fir (Abies balsamea L. Mill.) and spruce (Picea spp.) forests, susceptibility and vulnerability to spruce budworm infestations is reduced with increasing hardwood density. In mid-Atlantic oak-dominated forests, oak mortality following gypsy moth infestations was much greater in oak-dominated forests than in oak-pine mixedwoods, while pine mortality during southern pine beetle infestations was greater in pine-dominated forests than in oak-pine mixedwoods. Overall, mixedwood stands have greater resistance to infestations of defoliators and bark beetles and recover more rapidly from disturbances, reducing economic losses associated with tree mortality and mitigating short-term impacts to ecosystem functioning resulting from insect damage, especially carbon sequestration. Finally, we discuss challenges and opportunities for mixedwood management to minimize insect damage. Management strategies that incorporate mixedwood stands may provide better continuity in supply of forest products and ecosystem services in the face of projected increases in insect infestations associated with changing climate.