Sp transcription factor family and its role in cancer

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Sp transcription factor family and its role in cancer

Safe, Stephen; Abdelrahim, Maen

European journal of cancer (1990), 11/2005, Volume: 41, Issue: 16

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Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members of a family of transcription factors which bind GC/GT-rich promoter elements through three C 2H 2-type zinc fingers that are present at their C-terminal domains. Sp1–Sp4 proteins regulate expression of multiple genes in normal tissues and tumours. There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor. Sp/KLF proteins are also potential targets for cancer chemotherapy.

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