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Yakabe, T.; Moore, E.L.; Yokota, S.; Sui, H.; Nobuta, Y.; Fukao, M.; Palmer, H.; Yajima, N.
Food and chemical toxicology, 10/2009, Volume: 47, Issue: 10Journal Article
Lactobacillus brevis KB290 (KB290), a plant-derived probiotic lactic acid bacterium, reportedly improves gut health and stimulates immune function. Here we extensively investigated the geno-, acute, subacute, and subchronic toxicity of KB290 and its bacterial translocation potential. KB290 was non-mutagenic in the bacterial reverse mutation assay by the preincubation method. In the single oral dose toxicity test, KB290 at ⩾10 9 cfu/ml was nontoxic at maximum capacity (20 ml/kg). When 10 8, 10 9, or 10 10 cfu/kg was administered daily to rats by gavage for 2 weeks (subacute assay), we observed no clear treatment-related effect and no evidence of bacterial translocation from the gastrointestinal tract. When it was administered for 13 weeks (subchronic assay), we again observed no clear treatment-related effect and no significant toxicological effect. Based on those results, we consider 10 10 cfu/kg per day, the highest dose tested, to be the no observed adverse effect level (NOAEL). These results suggest that KB290 is safe for human consumption.
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