Catalytic C−H functionalization has emerged as an efficient alternative to traditional coupling reactions. However, some of these reactions depend on environmentally harmful solvents, weakening the overall green nature of these methods. As organic processes consume large amount of solvents, the use of less harmful solvents enhance the sustainability of these reactions. Herein, we present an overview of transition metal‐catalyzed C−H functionalization reactions for the synthesis of heterocycles in sustainable solvents based on CHEM21 solvent selection guide. Towards green: This Minireview highlights the improved greenness of the transition metal‐catalyzed C−H functionalization using sustainable solvent for the synthesis of heterocycles in a high atom‐ and step‐economical manner.