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Cha, Hee‐Jeong; Hwang, Se‐Yeun; Lee, Da‐Som; Kumar, Akula Ravi; Kwon, Yong‐Uk; Voß, Moritz; Schuiten, Eva; Bornscheuer, Uwe T.; Hollmann, Frank; Oh, Deok‐Kun; Park, Jin‐Byung
Angewandte Chemie, April 27, 2020, Volume: 59, Issue: 18Journal Article
Long‐chain aliphatic amines such as (S,Z)‐heptadec‐9‐en‐7‐amine and 9‐aminoheptadecane were synthesized from ricinoleic acid and oleic acid, respectively, by whole‐cell cascade reactions using the combination of an alcohol dehydrogenase (ADH) from Micrococcus luteus, an engineered amine transaminase from Vibrio fluvialis (Vf‐ATA), and a photoactivated decarboxylase from Chlorella variabilis NC64A (Cv‐FAP) in a one‐pot process. In addition, long chain aliphatic esters such as 10‐(heptanoyloxy)dec‐8‐ene and octylnonanoate were prepared from ricinoleic acid and oleic acid, respectively, by using the combination of the ADH, a Baeyer–Villiger monooxygenase variant from Pseudomonas putida KT2440, and the Cv‐FAP. The target compounds were produced at rates of up to 37 U g−1 dry cells with conversions up to 90 %. Therefore, this study contributes to the preparation of industrially relevant long‐chain aliphatic chiral amines and esters from renewable fatty acid resources. Playing the long game: Long‐chain aliphatic amines such as (S,Z)‐heptadec‐9‐en‐7‐amine and 9‐aminoheptadecane, as well as long‐chain aliphatic esters such as 10‐(heptanoyloxy)dec‐8‐ene and octylnonanoate, were prepared in high yields from ricinoleic acid and oleic acid by whole‐cell biocatalytic cascades using a photoactivated decarboxylase from Chlorella variabilis NC64A (Cv‐FAP) as a key enzyme in a one‐pot process. TA=transaminase, DH=dehydrogenase.
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