Human cancers express mutator phenotypes: origin, consequences and targeting

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Human cancers express mutator phenotypes: origin, consequences and targeting

Loeb, Lawrence A

Nature reviews. Cancer, 06/2011, Volume: 11, Issue: 6

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Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.

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Loeb, Lawrence A

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