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Bourreau, Eliane; Prévot, Ghislaine; Gardon, Jacques; Pradinaud, Roger; Launois, Pascal
The Journal of infectious diseases, 12/2001, Volume: 184, Issue: 12Journal Article
The intralesional expression of cytokines (interleukin IL–4, IL-13, IL-10, and interferon-γ) was analyzed in 65 patients with localized cutaneous leishmaniasis due to Leishmania guyanensis before specific treatment with pentamidine isethionate. The local expression of IL-10 was significantly higher in patients who responded poorly to treatment than in patients whose lesions were regressing. When an IL-10 level >10 (ratio of the concentration of IL-10 pg/μL to that of β-actin pg/μL) was used as an indicator of treatment failure, the sensitivity of this test was 78.6, and the specificity was 72.5. Thus, high intralesional expression of IL-10 might predict a poor response to conventional treatment
