E-resources
Peer reviewed
-
Anderson, Ana C.; Anderson, David E.; Bregoli, Lisa; Hastings, William D.; Kassam, Nasim; Lei, Charles; Chandwaskar, Rucha; Karman, Jozsef; Su, Ee W.; Hirashima, Mitsuomi; Bruce, Jeffrey N.; Kane, Lawrence P.; Kuchroo, Vijay K.; Hafler, David A.
Science (American Association for the Advancement of Science), 11/2007, Volume: 318, Issue: 5853Journal Article
CD4⁺ T helper 1 ($\text{T}_{\text{H}}1$) cells are important mediators of inflammation and are regulated by numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as an adjuvant during induced immune responses, and Tim-3 ligation induced distinct signaling events in T cells and dendritic cells; the latter finding could explain the apparent divergent functions of Tim-3 in these cell types. Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate$\text{T}_{\text{H}}1$immunity and may be able to influence a range of inflammatory conditions.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.