This article reports various cross sections of electron scattering from C5H10 isomers, viz. 1-pentene, 2-methyl-2-butene, cis-2-pentene, trans-2-pentene and 2-methyl-1-butene. These molecules are scarcely investigated in terms of such interactions, especially cis-2-pentene, trans-2-pentene and 2-methyl-1-butene molecules for which no previous cross section data is available. The results presented here are obtained by the quantum mechanical formalism using optical potential method, for a wide energy range from the ionization threshold of the target to 5000 eV. Geometrical screening correction is included in this calculation to account for the overlapping charge densities of different atoms present in a molecule. Most of the data presented here are reported for the first time. The effect of structural difference on cross section is investigated through isomeric effect. Display omitted •Theoretical studies of electron scattering from different C5H10 isomers are reported.•Cross sections for different channels are computed using Complex Optical Potential.•Cross section of cis and trans-2-pentene and 2-methyl-1-butene are reported for the first time.•Geometric screening correction is employed to refine the cross section.•The isomeric effect is visualized by comparing cross section to 2-methyl-2-butene.