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Beaurivage, Claudia; Champagne, Audrey; Tobelaim, William S.; Pomerleau, Véronique; Menendez, Alfredo; Saucier, Caroline
Cytokine (Philadelphia, Pa.), June 2016, 2016-Jun, 2016-06-00, 20160601, Volume: 82Journal Article
The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK–STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene.
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