Urine Xanthine Crystals in Tumor Lysis Syndrome

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Urine Xanthine Crystals in Tumor Lysis Syndrome

Omokawa, Ayumi; Oguma, Mariko; Ueki, Shigeharu; Saga, Tomoo; Hirokawa, Makoto

Urology (Ridgewood, N.J.), 10/2018, Volume: 120

Journal Article

Urine xanthine crystals are remarkably rare but can be observed by routine urine microscopy. We report the results of a 67-year-old man with T-cell-prolymphocytic leukemia whose urine contained xanthine crystals after chemotherapy and prophylactic administration of febuxostat. Accumulation of xanthine was due to tumor lysis syndrome causing a massive release of DNA. The metabolized DNA caused an increase of xanthine, which was not readily converted to uric acid by xanthine oxidase because of febuxostat inhibition of this enzyme.

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Omokawa, Ayumi | Oguma, Mariko | Ueki, Shigeharu | Saga, Tomoo | Hirokawa, Makoto

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