The charge particle (α) induced reactions on enriched copper (65Cu) are investigated for the production of 68Ga. The data sets of experimental cross sections are compiled, normalized and nuclear model analysis is done using calculational codes namely, ALICE-IPPE, TALYS 1.95 and EMPIRE 3.2. The theoretical production cross sections via alpha particle induced reactions are calculated to present a set of recommended cross sections. The calculated cross sections are utilized to deduce thick target yield (TTY) for the 65Cu (α, n) 68Ga reaction. The range of energy for production of 68Ga is suggested up to 40 MeV having least contribution of radio-impurities. •Compilation of the excitation functions of 65Cu(α, n)68Ga reaction from all available experimental data.•Theoretical production cross sections are calculated using ALICE-IPPE, TALYS-1.95, EMPIRE-3.2.•The contributions of radio-nuclidic impurities are discussed.•Recommended cross sections have been deduced.•Thick target yield is estimated from the recommended cross sections.