E-resources
Peer reviewed
-
Xiang, Huan; Yu, Zhengkai; Xie, Tian; Ye, Xiang‐Yang; Ye, Yang
European journal of organic chemistry, October 13, 2022, Volume: 2022, Issue: 38Journal Article
A facile and efficient method is presented for the synthesis of 6‐alkylated phenanthridine, possessing hindered quaternary carbon centers, by Zn‐mediated reductive trapping of tertiary alkyl radicals with both electron‐rich and electron‐deficient aryl isocyanides using nickel as a promoter. Bench‐stable and operation‐friendly tertiary alkyl oxalates derived from abundant tertiary alkyl alcohols were first used as radical precursors for the alkylation of isocyanobiphenyl species. This reaction displays excellent functional group tolerance and broad substrate scope, allowing access to desired products in good to excellent yields. The efficient radical cascade cyclization protocol for the reductive cleavage of C−O bonds followed by phenanthridine formation is reported. The method involves generating tertiary alkyl radical intermediates that are invoked by single‐electron reduction by Zn, wherein MgCl2 serves as the indispensable additive and nickel as the promoter. The reaction displays excellent functional group tolerance and broad substrate scope.
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.