Elaiomycins D–F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp. Strain HKI0708

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Elaiomycins D–F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp. Strain HKI0708

Ding, Ling; Ndejouong, Basile Le Sage Tchize; Maier, Armin; Fiebig, Heinz-Herbert; Hertweck, Christian

Journal of natural products (Washington, D.C.), 10/2012, Volume: 75, Issue: 10

Journal Article

Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure–activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.

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Ding, Ling | Ndejouong, Basile Le Sage Tchize | Maier, Armin | Fiebig, Heinz-Herbert | Hertweck, Christian

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