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Solis, Carlos M.; Salazar, Mario O.; Ramallo, I. Ayelen; García, Paula; Furlan, Ricardo L. E.
European journal of organic chemistry, July 7, 2022, Volume: 2022, Issue: 25Journal Article
Concomitant selective dehydroxylation during the transformation of flavones into pyrazoles with hydrazine is determined by the A‐ring substitution pattern and propensity to keto enol tautomerization. The obtained pyrazoles show varied tyrosinase inhibition properties, including one nanomolar inhibitor. Concomitant selective dehydroxylation during the transformation of flavones into pyrazoles with hydrazine is determined by the A‐ring substitution pattern and propensity to keto–enol tautomerization. The obtained pyrazoles show varied tyrosinase inhibition properties, including one nanomolar inhibitor.
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