•Interventions for pregnant youth and young mothers facing housing instability or homelessness primarily focus on offering housing alongside support services.•When housing interventions incorporate supportive elements like case management, notable enhancement in health and employment outcomes for the youth are noted compared to housing-only initiatives.•Interventions offering in-home or school-based parental support yield positive outcomes for participants.•Interventions for pregnant youth and young mothers facing homelessness are crucial, not only for their well-being but also to reduce the intergenerational risk of homelessness for their children. Pregnant youth and young mothers facing housing instability or homelessness encounter unique challenges that result in adverse health, educational, and employment consequences for both them and their children. This systematic review aimed to consolidate the available evidence on effective and promising interventions to prevent homelessness amongst youth who are pregnant or young mothers with children under 6 years old and assist those facing homelessness. This review encompassed 10 studies that revolved around two primary themes: housing and supportive services, such as case management (n = 6), and parental services, including childcare provision or parenting classes (n = 4). We found that housing strategies incorporating counselling and case management notably enhanced participants' substance use patterns, mental health, healthcare access, and employment trajectories. Comparatively, housing services without supportive services did not lead to improvements within the participants. Parental services such as family home visits significantly reduced homelessness for participating families. School-based programs that offer childcare and supportive services improved maternal academic outcomes, reduced the incidence of subsequent pregnancies, and fostered positive parenting practices. Mobile technology also appeared promising in enhancing the emotional and behavioural capabilities of the youth. In conclusion, interventions targeting young expectant individuals and mothers, whether at risk or already experiencing homelessness, primarily emphasize housing combined with supportive services and parenting assistance.