•Among the different mycotoxin reducing methods, we should not declare that one individual method is unconditionally effective to eliminate mycotoxin contamination in crops or to prevent the consequent impacts on animal health.•Prevention strategies and cleaning and sorting methods are widely applied because they work as first-line barriers to free materials from various contaminants, including mycotoxins.•Mycotoxin reducing effects of other feed manufacturing technologies, like milling, dehulling and thermal methods, could be inconsistent and limited by various practical conditions. In addition, the evident reducing effects of some physical removal methods requires the costs of high grain mass loss, which could be a dilemma from the aspect of practical manufacturing.•Feed additive products specifically against mycotoxins are promising but still in their babyhood, since in vitro functioning of some products are inconsistent, and their in vivo functioning need more proof.•As for biotransformation, understanding the reaction for the detoxification of mycotoxins, attention in research on the toxicity of transformation by enzymes and their end-products should emphasize the possibilities of the use of micro-organisms or enzymes towards safe properties in animal feed ingredients.•This literature review generally agrees with the discussion of Jouany (2007): ‘Prevention strategies are essential, since it is impossible for other technologies to completely decontaminate the mycotoxin-contaminated feed samples once they are present’. Mycotoxins are the secondary metabolites of fungi, especially moulds. They have over 300 types and can be easily produced ubiquitously by moulds. Many mycotoxins have been found to be toxic to most farmed animals through the diets. With the globalization of feed ingredient trade and the rapid climate changes, occurrence of mycotoxins become increasingly difficult to be predicted. Thus, the unnoticeable mycotoxin hazards can directly impact the animal production systems. Preventing or minimizing mycotoxins in feed ingredients has become an important topic from the aspect of feed manufacturing industry. The aim of this literature review is to summarize the effective strategies for feed manufacturers to minimize the mycotoxin hazards. Prevention methods, including pre-harvest field management and post-harvest storage management, are still the most effective strategies, since mycotoxins are hardly to be eliminated once they are present in the ingredients. Moreover, mycotoxin reducing effects of several feed manufacturing technologies are also reviewed. In this review, the mycotoxin reducing methods are mainly categorized into 4 methodologies: physical methods, thermal methods, chemical methods, and mycotoxin controlling feed additives. The first three methodologies mainly focus on how to reduce mycotoxins in feed ingredients during processes, while the last one on how to compensate the adverse impacts of mycotoxin-contaminated diets in animal bodies. The results showed that most of the methods reviewed show evident mycotoxin reducing effects, but of different consistencies. On the other hand, many practical factors that can affect the feasibility of each method in practical manufacturing are also discussed in this review. In conclusion, mycotoxin prevention management and the processing stage of cleaning and sorting are still the most efficient strategies to control mycotoxin hazards in current feed manufacturing.