E-resources
Peer reviewed
-
Han, Xue; Lou, Qi; Feng, Feng; Xu, Guanhua; Hong, Song; Yao, Li; Qin, Shijie; Wu, Dazhuan; Ouyang, Xiaoping; Zhang, Zhiguo; Wang, Xiuyu
Angewandte Chemie International Edition, August 15, 2022, Volume: 61, Issue: 33Journal Article
The heterogeneity in biofilms is a major challenge in biofilm therapies due to different susceptibility of bacteria and extracellular polymeric substances (EPS) to antibacterial agents. Here, we describe a therapeutic strategy that overcame biofilm heterogeneity, where antibacterial agent (NO) and EPS dispersant (reactive oxygen species (ROS)‐inducing Fe3+) were separately loaded in the yolk and shell compartment of a yolk–shell nanoplatform. Compared with traditional combinational chemotherapies which suffer from inconsistent pharmacokinetics profiles, this strategy drew on the pharmacokinetic complementarity of ROS and NO, where ROS with a short diffusion distance and a high redox potential corrupted the EPS, facilitating NO, which has a long diffusion distance and a broad antimicrobial spectrum, to penetrate the biofilm and eliminate the resident bacteria. Additionally, the construction of a three‐dimensional spherical biofilm model is novel and clinically relevant. A therapeutic strategy to overcome biofilm heterogeneity is presented, in which antibacterial agent (NO) and extracellular polymeric substances (EPS) dispersant (reactive oxygen species (ROS)‐inducing Fe3+) are separately loaded in the yolk and shell compartment of a yolk–shell nanoplatform. The spatiotemporally ordered release manner and pharmacokinetic complementarity of ROS and NO improve the anti‐biofilm outcome synergistically.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.