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Murata, Toshiki; Shimada, Mitsuyuki; Sakakibara, Sachiko; Yoshino, Takashi; Kadono, Hiroshi; Masuda, Tsutomu; Shimazaki, Makoto; Shintani, Takuya; Fuchikami, Kinji; Sakai, Katsuya; Inbe, Hisayo; Takeshita, Keisuke; Niki, Toshiro; Umeda, Masaomi; Bacon, Kevin B.; Ziegelbauer, Karl B.; Lowinger, Timothy B.
Bioorganic & medicinal chemistry letters, 03/2003, Volume: 13, Issue: 5Journal Article
IκB kinase β (IKK-β) is a serine-threonine protein kinase critically involved in the activation of the transcription factor Nuclear Factor kappa B (NF-κB) in response to various inflammatory stimuli. We have identified a small molecule inhibitor of IKK-β. Optimization of the lead compound resulted in improvements in both in vitro and in vivo potency, and provided IKK-β inhibitors exhibiting potent activity in an acute cytokine release model (LPS-induced TNFα). Graphic
