E-resources
Peer reviewed
-
Feng, Guangxue; Wang, Can; Chen, Chengjian; Pan, Yutong; Wu, Min; Wang, Yuanbo; Liu, Jie; Liu, Bin
Chemistry of materials, 12/2020, Volume: 32, Issue: 24Journal Article
The precise treatment of cancer requires maximized lesion to cancer cells and minimized damage to normal cells; however, the current theranostic nanomaterials have limited generic theranostic specificity to cancer cells. Herein, as a proof of concept, a small-molecular system simultaneously possessing on-site fluorescence light-up feature, universal cancer cell selectivity, controllable subcellular localization, and activated therapeutic function is developed for cancer theranostics. These molecular probes are composed of photosensitizers (PSs) with the aggregation-induced emission (AIE) feature as the core and aliphatic chains containing lipophilic cations as the arms, which show fluorescence light-up upon entering cancer cells. The charges and lipophilicity of these light-up probes are fine-tuned by the number of lipophilic cations, which modulate their cancer cell selectivity and subcellular localization, where the synthesized AIE PS with four positive charges (TPETM-4+) shows the highest differentiation toward all tested cancer cells over normal ones; neutrally charged TPETM-2 with two arms stains the cytoplasm, TPETM-2+ with two positive charges stains the mitochondria, while TPETM-4+ labels the lysosome. Moreover, under light irradiation, TPETM-4+ exhibits specific photodynamic ablation toward cancer cells over normal ones. This study proposes a new approach to design delivery systems for generic cancer cell selectivity with subcellular localization control, which opens up new opportunities for precise cancer therapy.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.