Nowadays, pharmaceuticals are the center of significant environmental research due to their complex and highly stable bioactivity, increasing concentration in the water streams and high persistence in aquatic environments. Conventional wastewater treatment techniques are generally inadequate to remove these pollutants. Aiming to tackle this issue effectively, various methods have been developed and investigated on the light of chemical, physical and biological procedures. Increasing attention has recently been paid to the advanced oxidation processes (AOPs) as efficient methods for the complete mineralization of pharmaceuticals. Their high operating costs compared to other processes, however, remain a challenge. Hence, this review summarizes the current and state of art related to AOPs, biological treatment and their effective exploitation for the degradation of various pharmaceuticals and other emerging molecules present in wastewater. The review covers the last decade with a particular focus on the previous five years. It is further envisioned that this review of advanced oxidation methods and biological treatments, discussed herein, will help readers to better understand the mechanisms and limitations of these methods for the removal of pharmaceuticals from the environment. In addition, we compared AOPs and biological treatments for the disposal of pharmaceuticals from the point of view of cost, effectiveness, and popularity of their use. The exploitation of coupling AOPs and biological procedures for the degradation of pharmaceuticals in wastewater was also presented. It is worthy of note that an integrated AOPs/biological system is essential to reach the complete degradation of pharmaceuticals; other advantages of this hybrid technique involve low energy cost, an efficient degradation process and generation of non-toxic by-products. Display omitted •Pharmaceutical compounds in different water matrices contribute to ecotoxicity.•Water treatment plants are efficient to reduce but not remove pharmaceuticals present in water.•Removal of pharmaceuticals by advanced oxidation processes (AOPs) from wastewater appears efficient.•Biological processes are promising techniques in the removal of pharmaceuticals.•The hybrid AOPs/biological system is economical and efficiency for complete degradation.