Mechanisms of action of intravenous immunoglobulin

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Mechanisms of action of intravenous immunoglobulin

Chaigne, Benjamin; Mouthon, Luc

Transfusion and apheresis science, 02/2017, Volume: 56, Issue: 1

Journal Article

Abstracts Taking advantage of the “World Apheresis Association/Société Française d’Hémaphérèse” meeting held in Paris in April 2016, this article reviews the current knowledge on the mechanisms of action of intravenous immunoglobulins. Immunoglobulins are a plasma-derived drug, which have been initially used as a replacement therapy for patients with antibody deficiency. Since 1980 they have also been used for their anti-inflammatory and immunomodulating efficacy in auto-immune diseases. Herein, we review the requirements for their production and composition before giving a specific attention to their mechanisms of action including substitution and immunomodulation.

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