Biodegradability of graphene is one of the fundamental parameters determining the fate of this material in vivo. Two types of aqueous dispersible graphene, corresponding to single‐layer (SLG) and few‐layer graphene (FLG), devoid of either chemical functionalization or stabilizing surfactants, were subjected to biodegradation by human myeloperoxidase (hMPO) mediated catalysis. Graphene biodegradation was also studied in the presence of activated, degranulating human neutrophils. The degradation of both FLG and SLG sheets was confirmed by Raman spectroscopy and electron microscopy analyses, leading to the conclusion that highly dispersed pristine graphene is not biopersistent. Not biopersistent: Two types of aqueous dispersible graphene, corresponding to single layer (SLG) and few layer graphene (FLG), devoid of either chemical functionalization or stabilizing surfactants, were subjected to biodegradation. Graphene can be degraded by human myeloperoxidase secreted by activated neutrophils, indicating that this material is not biopersistent.