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Xu, Xin‐Yue; Li, Xuan; Wang, Jia; He, Xiao‐Tao; Sun, Hai‐Hua; Chen, Fa‐Ming
Stem cells translational medicine, April 2019, Volume: 8, Issue: 4Journal Article
Periodontitis is a widespread disease characterized by inflammation‐induced progressive damage to the tooth‐supporting structures until tooth loss occurs. The regeneration of lost/damaged support tissue in the periodontium, including the alveolar bone, periodontal ligament, and cementum, is an ambitious purpose of periodontal regenerative therapy and might effectively reduce periodontitis‐caused tooth loss. The use of stem cells for periodontal regeneration is a hot field in translational research and an emerging potential treatment for periodontitis. This concise review summarizes the regenerative approaches using either culture‐expanded or host‐mobilized stem cells that are currently being investigated in the laboratory and with preclinical models for periodontal tissue regeneration and highlights the most recent evidence supporting their translational potential toward a widespread use in the clinic for combating highly prevalent periodontal disease. We conclude that in addition to in vitro cell‐biomaterial design and transplantation, the engineering of biomaterial devices to encourage the innate regenerative capabilities of the periodontium warrants further investigation. In comparison to cell‐based therapies, the use of biomaterials is comparatively simple and sufficiently reliable to support high levels of endogenous tissue regeneration. Thus, endogenous regenerative technology is a more economical and effective as well as safer method for the treatment of clinical patients. Stem Cells Translational Medicine 2019;8:392–403 Periodontal regeneration can potentially be achieved via either the in vitro design of cell‐material constructs that may undergo remodeling and revascularization to integrate with the host tissue following transplantation or based on the in vivo manipulation of the cell‐material interplay at the target site to recruit endogenous stem cells to regenerate new tissues.
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