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Roselli, Jenny; Innocenti, Tommaso; Lynch, Erica Nicola; Parisio, Laura; Apolito, Pasquale; Mello, Tommaso; Macrì, Giuseppe; Milla, Monica; Biagini, Maria Rosa; Tarocchi, Mirko; Milani, Stefano; Galli, Andrea
Case reports in gastrointestinal medicine, 04/2020, Volume: 2020Journal Article
Stevens–Johnson syndrome (SJS) is a severe mucocutaneous adverse drug reaction with a relatively high mortality rate. SJS is described during herpes simplex virus type 1 (HSV1) infection and, rarely, even during adalimumab therapy. We report the case of a patient with Crohn’s disease who developed SJS during an HSV1 infection and a contemporaneous anti-TNFα therapy with adalimumab. Remission was achieved with suspension of adalimumab and high doses of intravenous steroids and antivirals. Patients with HSV1 infection and on adalimumab therapy have a combined risk of SJS and should be monitored closely.
