E-resources
-
Li, Yafang; Xiao, Xiangjun; Li, Jianrong; Byun, Jinyoung; Cheng, Chao; Bossé, Yohan; McKay, James; Albanes, Demetrios; Lam, Stephen; Tardon, Adonina; Chen, Chu; Bojesen, Stig E; Landi, Maria T; Johansson, Mattias; Risch, Angela; Bickeböller, Heike; Wichmann, H-Erich; Christiani, David C; Rennert, Gad; Arnold, Susanne; Goodman, Gary; Field, John K; Davies, Michael P A; Shete, Sanjay S; Le Marchand, Loic; Melander, Olle; Brunnström, Hans; Liu, Geoffrey; Hung, Rayjean J; Andrew, Angeline S; Kiemeney, Lambertus A; Shen, Hongbing; Sun, Ryan; Zienolddiny, Shan; Grankvist, Kjell; Johansson, Mikael; Caporaso, Neil; Teare, Dawn M; Hong, Yun-Chul; Lazarus, Philip; Schabath, Matthew B; Aldrich, Melinda C; Schwartz, Ann G; Gorlov, Ivan; Purrington, Kristen; Yang, Ping; Liu, Yanhong; Han, Younghun; Bailey-Wilson, Joan E; Pinney, Susan M; Mandal, Diptasri; Willey, James C; Gaba, Colette; Brennan, Paul; Amos, Christopher I
Human molecular genetics, 08/2022, Volume: 31, Issue: 16Journal Article
Abstract Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene–sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 odds ratio (OR) = 0.71, P = 4.29×10−8); rs79942605 (OR = 2.17, P = 2.81×10−8) and rs208908 (OR = 0.70, P = 4.54×10−8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.