E-resources
-
Puig, Isabel; Tenbaum, Stephan P; Chicote, Irene; Arqués, Oriol; Martínez-Quintanilla, Jordi; Cuesta-Borrás, Estefania; Ramírez, Lorena; Gonzalo, Pilar; Soto, Atenea; Aguilar, Susana; Eguizabal, Cristina; Caratù, Ginevra; Prat, Aleix; Argilés, Guillem; Landolfi, Stefania; Casanovas, Oriol; Serra, Violeta; Villanueva, Alberto; Arroyo, Alicia G; Terracciano, Luigi; Nuciforo, Paolo; Seoane, Joan; Recio, Juan A; Vivancos, Ana; Dienstmann, Rodrigo; Tabernero, Josep; Palmer, Héctor G
The Journal of clinical investigation, 09/2018, Volume: 128, Issue: 9Journal Article
Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. We have adapted the pulse-chase expression of H2BeGFP for labeling and isolating slow-cycling cancer cells (SCCCs). SCCCs showed cancer initiation potential and enhanced chemoresistance. Cells at this slow-cycling status presented a distinctive nongenetic and cell-autonomous gene expression profile shared across different tumor types. We identified TET2 epigenetic enzyme as a key factor controlling SCCC numbers, survival, and tumor recurrence. 5-Hydroxymethylcytosine (5hmC), generated by TET2 enzymatic activity, labeled the SCCC genome in carcinomas and was a predictive biomarker of relapse and survival in cancer patients. We have shown the enhanced chemoresistance of SCCCs and revealed 5hmC as a biomarker for their clinical identification and TET2 as a potential drug target for SCCC elimination that could extend patients' survival.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.