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Xiang, Jian-Feng; Yin, Qing-Fei; Chen, Tian; Zhang, Yang; Zhang, Xiao-Ou; Wu, Zheng; Zhang, Shaofeng; Wang, Hai-Bin; Ge, Junhui; Lu, Xuhua; Yang, Li; Chen, Ling-Ling
Cell research, 05/2014, Volume: 24, Issue: 5Journal Article
The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus is regulated remains poorly understood. Here we demonstrate that a long noncoding RNA (lncRNA), CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC. This lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition, CCAT1-L interacts with CTCF and modulates chromatin conformation at these loop regions. These results reveal an important role of a previously unannotated lncRNA in gene regulation at the MYC locus.
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