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Song, Junke; Zhang, Li; Xu, Yanfeng; Yang, Dezhi; Zhang, Li; Yang, Shiying; Zhang, Wen; Wang, Jinhua; Tian, Shuo; Yang, Shengqian; Yuan, Tianyi; Liu, Ailin; Lv, Qi; Li, Fengdi; Liu, Hongqi; Hou, Biyu; Peng, Xiaozhong; Lu, Yang; Du, Guanhua
Biochemical pharmacology, 01/2021, Volume: 183Journal Article
Display omitted Baicalein is the main active compound of Scutellaria baicalensis Georgi, a medicinal herb with multiple pharmacological activities, including the broad anti-virus effects. In this paper, the preclinical study of baicalein on the treatment of COVID-19 was performed. Results showed that baicalein inhibited cell damage induced by SARS-CoV-2 and improved the morphology of Vero E6 cells at a concentration of 0.1 μM and above. The effective concentration could be reached after oral administration of 200 mg/kg crystal form β of baicalein in rats. Furthermore, baicalein significantly inhibited the body weight loss, the replication of the virus, and relieved the lesions of lung tissue in hACE2 transgenic mice infected with SARS-CoV-2. In LPS-induced acute lung injury of mice, baicalein improved the respiratory function, inhibited inflammatory cell infiltration in the lung, and decreased the levels of IL-1β and TNF-α in serum. In conclusion, oral administration of crystal form β of baicalein could reach its effective concentration against SARS-CoV-2. Baicalein could inhibit SARS-CoV-2-induced injury both in vitro and in vivo. Therefore, baicalein might be a promising therapeutic drug for the treatment of COVID-19.
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