E-resources
-
Correa, Stephanie M.; Newstrom, David W.; Warne, James P.; Flandin, Pierre; Cheung, Clement C.; Lin-Moore, Alexander T.; Pierce, Andrew A.; Xu, Allison W.; Rubenstein, John L.; Ingraham, Holly A.
Cell reports, 01/2015, Volume: 10, Issue: 1Journal Article
Estrogen-receptor alpha (ERα) neurons in the ventrolateral region of the ventromedial hypothalamus (VMHVL) control an array of sex-specific responses to maximize reproductive success. In females, these VMHVL neurons are believed to coordinate metabolism and reproduction. However, it remains unknown whether specific neuronal populations control distinct components of this physiological repertoire. Here, we identify a subset of ERα VMHVL neurons that promotes hormone-dependent female locomotion. Activating Nkx2-1-expressing VMHVL neurons via pharmacogenetics elicits a female-specific burst of spontaneous movement, which requires ERα and Tac1 signaling. Disrupting the development of Nkx2-1+ VMHVL neurons results in female-specific obesity, inactivity, and loss of VMHVL neurons coexpressing ERα and Tac1. Unexpectedly, two responses controlled by ERα+ neurons, fertility and brown adipose tissue thermogenesis, are unaffected. We conclude that a dedicated subset of VMHVL neurons marked by ERα, NKX2-1, and Tac1 regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses. Display omitted •Stimulating female Nkx2-1+ VMHVL neurons via DREADDs elicits a burst of movement•ERα hormone signaling and Tac1 are required for DREADD-induced locomotion•Loss of ERα, Tac1, and NKX2-1 neurons in the VMHVL leads to inactive, obese females•A VMHVL module controls female activity, but not reproduction or BAT thermogenesis Metabolism and reproduction are tightly linked in females and regulated by estrogen-responsive neurons in the ventrolateral region of the ventromedial hypothalamus (VMHVL). Correa et al. identify a neuronal subpopulation in the VMHVL marked by NKX2-1, ERα, and Tac1 that is dedicated to driving estrogen-dependent fluctuations in female physical activity.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.