Cerebral apolipoprotein E and amyloid precursor-like protein 1 as risk factors for chronic neurodegeneration after non-traumatic acute brain injury (ABI)

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Cerebral apolipoprotein E and amyloid precursor-like protein 1 as risk factors for chronic neurodegeneration after non-traumatic acute brain injury (ABI)

Santacruz, Carlos A; Vincent, Jean-Louis; Imbault, Virginie; Bruneau, Michael; Creteur, Jacques; Brimioulle, Serge; Vincent, Raussens; Communi, David; Taccone, Fabio S

Critical care (London, England), 06/2023, Volume: 27, Issue: 1

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Lipidated ApoE binds to soluble Aβ and facilitates Aβ uptake through cell surface receptors, including low-density lipoprotein receptor (LDLR), LDLR-related protein 1 (LRP1), and heparan sulphate proteoglycan 4. ...the GOS is a measure of functional outcome rather than neurocognitive outcome and may not be the most suitable measure for assessing correlations between proteomic profiles and risk of developing neurocognitive disease. ...not all the analyzed vCSF samples gave an ELISA result, which may have introduced a bias in the results. ...the sample size was too small to allow normalization for age or comorbidities 1.

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