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Oh, Gabriel; Ebrahimi, Sasha; Carlucci, Matthew; Zhang, Aiping; Nair, Akhil; Groot, Daniel E; Labrie, Viviane; Jia, Peixin; Oh, Edward S; Jeremian, Richie H; Susic, Miki; Shrestha, Tenjin C; Ralph, Martin R; Gordevičius, Juozas; Koncevičius, Karolis; Petronis, Art
Nature communications, 02/2018, Volume: 9, Issue: 1Journal Article
Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism's deterioration.
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