Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

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Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

Cai, H.-Y; Hölscher, C; Yue, X.-H; Zhang, S.-X; Wang, X.-H; Qiao, F; Yang, W; Qi, J.-S

Neuroscience, 09/2014, Volume: 277

Journal Article

Highlights • Lixisenatide, a novel drug treatment for diabetes, shows neuroprotective effects. • Lixisenatide prevented the Aβ25–35 induced impairment in spatial learning. • The drug prevented the Aβ25–35 induced block of LTP in the hippocampus. • The drug inhibited the Aβ25–35 induced activation of glycogen synthase kinase 3β.

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