Lymphedema is a chronic and progressive1 pathology, the diagnosis of which, in some cases, can occur late, also due to the lack of a unique diagnostic path. For these reasons it may be difficult to establish the exact prevalence within the general population2 also in relation to the complex differential diagnosis with phlebostatic and lipostatic pathologies3. During 2020, due to the SARS-CoV-2 (COVID-19) pandemic, the increased diagnostic latencies were accompanied by a difficulty in taking care of these patients, as a consequence of the restrictive measures imposed during the lockdown for the 'sanitary emergency. The reduction of outpatient activities for clinical problems considered non-urgent has further extended the timing of the diagnostic and therapeutic process for these patients, influencing, in some cases, the establishment of particularly complex clinical pictures. The objective of this case report is to describe the clinical history of a young patient with primary lymphedema arising in the lower limb contralateral to the one affected by a knee sprain trauma, documenting the effectiveness of Complex Decongestive Therapy (CDT) and describing a therapeutic opportunity in the choice of elastic-compression devices. Lymphedema is a disease characterized by an excessive accumulation of histolymph, due to an obstruction or a malformation of the peripheral lymphatic system, which can be localized in different parts of the body, including: the upper limbs, the lower limbs, the neck and the genitals .