A series of three giant, previously unrecognized submarine landslides are defined on a 16,000 line km grid of multi-channel 2D seismic reflection profiles along the active margin of northern Colombia in the western Caribbean Sea. These deposits record the collapse and mobilization of immense segments (thousands of cubic kilometers) of the submarine slope and are comparable in scale to the largest known landslides on Earth. We show that the breakaway zone for these events corresponds to the tectonically over-steepened slopes of the Magdalena Fan, an extensive submarine fan composed of sediments sourced from the northern Andes and deposited by the Magdalena River. An over-pressured zone of weakness at the base of the gas-hydrate stability layer within the fan likely facilitates slope failure. Timing of these massive slope failures is constrained by well control and occurred from the mid-to-late Pliocene to mid-Pleistocene. To understand the tsunamigenic hazards posed by the recurrence of such an event today, we model the potential tsunami source created by a submarine landslide of comparable thickness (400 m) and lateral extent (1700 km2) derived from the over-steepened upper slopes of the present day Magdalena Fan. Our modeling indicates the recurrence of an analogous slope failure would result in a major tsunami that would impact population centers along the Caribbean coastlines of Colombia, Central America, and the Greater Antilles with little advance warning. •Three giant submarine landslides are recognized off the Caribbean coast of Colombia.•Volume of material mobilized ranks within top 5–10% of global occurrences.•Timing of events is constrained from late Pliocene to Pleistocene.•Source for slides is interpreted as the submarine slopes of the Magdalena River Fan.•Tsunami modeling indicates a recurrent slide would devastate Caribbean coastlines.