Delay in sowing and low precipitation (<300mm annual) in wheat (Triticum aestivum L.) farming is the major problem in the irrigated and rainfall lands of Iran. A factorial experiment for evaluating the effects of seed priming on wheat cultivars was carried out under laboratory, greenhouse and at two field conditions during seasons of 2008-2010. Arrangement of treatments were Zarrin, Shariar, Sardary and Azar cultivars as A factor, and priming treatments including distilled water (DW), osmotic solutions (10% PEG, 2.5% KCl, 4% MN, 10% Urea, 5% NaCl W/V) and plant growth inducers (20 ppm IAA, 1000 ppm CCC) with non-primed seed as a control established B factor. During the second year of field experiment two separate treatments were done under drought stress and well watered conditions. Drought stress was withheld by irrigation at booting stage of plants. Maximum amount of absorbed water was determined in cultivar Shariar, 15.5 g DW. Seed weight of all cultivars increased the most when primed with CCC and IAA. Irrespective of the cultivar seedlings related traits revealed that treatment with CCC increased plumule and radical dry weights (11.5 and 8.0 mg) and their lengths (17.2 and 17.8 cm). In opposite, urea pretreatment had negative effects on seedlings growth. All priming treatments increased grain yield and its components, chlorophyll content and nitrogen absorbed under field and green house conditions in four cultivars in comparison to control. Plants arising from seeds primed with potassium chloride under drought stress had the lowest percentage of variation for traits such as relative water content (-9.3%), total dry matter (-10.7%) and grain yield (-4.0%) in comparison with well watered plants. Potassium chloride improved drought tolerance at all wheat cultivars. There were significant correlations between grain yield at primed with KCl and following wheat traits: number of spikes per square meter (0.91**), number of grains per spike (0.92**) and total dry matter (0.79*). Therefore, it seems that these traits could be used as indirect criteria for selection of high grain yield of cultivars for primed seed. Zakasnitev v setvi in majhna količina padavin (<300mm letno) sta glavna problema pri pridelavi pšenice (Triticum aestivum L.) v namakanih in nenamakanih območjih Irana. Izvrednotenje učinka predsetvenega tretiranja semena izbranih sort pšenice je bilo narejeno s faktorskim poskusom v laboratoriju, rastlinjaku in v dveh poljskih poskusih v sezonah 2008-2010. Poskus je bil zastavljen s štirimi sortami pšenice (Zarrin, Shariar, Sardary in Azar) kot faktorjem A in predsetvenimi tretmaji, ki so obsegali destilirano vodo (DW), raztopine osmotikov (0% Urea, 5% NaCl W/V) in rastlinske rastne regulatorje (20 ppm IAA, 1000 ppm CCC) primerjalno z netretiranimi semeni, kar je bila kontrola in faktor B. V drugem letu poljskega poskusa sta bili opravljeni še obravnavi s sušo in zadostnim zalivanjem. Sušni stres je bil preprečen z zalivanjem v fazi bilčenja. Največ absorbirane vode je bilo izmerjeno pri sorti Shariar, 15.5 g DW. Teža semen vseh sort se je povečala najbolj, kadar so bila semena pred setvijo tretirana s CCC in IAA. Ne glede na sorto se je pokazalo, da sta se suha teža mladega poganjka in korenine (11.5 in 8.0 mg) pri kalicah povečali kot tudi njuni dolžini (17.2 in 17.8 cm) kadar je bilo seme pretretirano s CCC. Nasprotno je imelo predtretiranje z ureo negativni učinek na rast kalic. Vsa predtretiranja so povečala pridelek zrnja in njegove komponente, vsebnost klorofila in privzetje dušika v poskusih v rastlinjaku in poljskem poskusu pri vseh sortah v primerjavi s kontrolo. Rastline, ki so zrasle iz semen predtretiranih s KCl v razmerah sušnega stresa so imele najmanjši odstotek variabilnosti v znakih kot so reletivna vsebnost vode (-9.3%), celokupna suha snov (-10.7%) in pridelek zrnja (-4.0%) v primerjavi z dobro zalivanimi rastlinami. Natrijev klorid je pri vseh sortah pšenice izboljšal prenašanje suše. Ugotovljene so bile značilne korelacije med pridelkom zrnja pšenice, ki je bila predtretirana s KCl in naslednjimi znaki pridelka: število klasov na kvdratni meter (0.91**), število zrn na klas (0.92**) in celokupno suho snov (0.79*). Zato izgleda, da bi lahko te znake uporabili kot posredni kriterij za izbor visokoproduktivnih sort pšenice, pri katerih se seme predtretira.