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Vamecq, Joseph; Masso, Vincent; Bancel, Léo-Paul; Jannin, Arnaud; Dessein, Anne-Frédérique; Cardot-Bauters, Catherine; Pigny, Pascal
Biochimie, October 2022, 2022-10-00, 20221001, Volume: 201Journal Article
Apart from the oncometabolite succinate, little studies have appeared on extra-mitochondrial pathways in Succinate Dehydrogenase (SDH) genetic deficiency. The role of NADH/NAD+ redox status and dependent pathways was recently emphasized. Therein, fatty acid (FA) metabolism data were collected here in 30 patients with a loss of function (LOF) variant in one SDHx gene (either with a pheochromocytoma/paraganglioma (PPGL) or asymptomatic) and in 22 wild-type SDHx controls (with PPGL or asymptomatic). Blood acylcarnitines in two patients, peroxisomal biomarkers, very long-chain saturated FA (VLCFA), and C20 to C24 n-3 polyunsaturated fatty acids (PUFA), in all patients were measured by mass spectrometry. Preliminary data showed elevated even and odd long- and very long-chain acylcarnitines in two patients with a SDHB variant. In the whole series, no abnormalities were observed in biomarkers of peroxisomal β-oxidation (C27-bile acids, VLCFAs and phytanic/pristanic acids) in SDHx patients. However, an increased hexaene to pentaene PUFA ratio (TetraHexaenoic Acid + DocosaHexaenoic Acid/n-3 DocosaPentaenoic Acid + EicosaPentaenoic Acid) was noticed in patients with SDHC/SDHD variants vs patients with SDHA/SDHB variants or controls, suggesting a higher degree of unsaturation of PUFAs. Within the group with a SDHx variant, Eicosapentaenoate/Tetracosahexaenoate ratio, as an empiric index of shortening/elongation balance, discriminated patients with PPGL from asymptomatic ones. Present findings argue for stimulated elongation of saturated FAs, changes in shortening/elongation balance and desaturation rates of C20–C24 PUFAs in SDH-deficient patients with PPGL. Overall, oxidation of NADH sustained by these pathways might reflect or impact glycolytic NAD+ recycling and hence tumor proliferation. •Unsaturation of serum C20–C24 PUFAs is higher in patients with SDHC/D germline variant.•Serum EPA/THA ratio increases in patients with germline SDHx variant and paraganglioma.•This suggests higher Fatty Acid desaturase and elongase activities in SDH deficiency.•Both biochemical pathways increase cytosolic NAD + recycling.
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