The present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum. AR patients (n=24) and healthy subjects (n=12) were recruited and serum samples were collected. The serum level of IgE specific for inhalant allergens was determined using the automatic quantitative immunofluorescence analysis system, and the contents of IL-17, IL-21 and IL-23 in the serum were detected using ELISA. The level of serum IgE in the healthy individuals was categorized as grade 0 and that in the AR patients as grade 2-6. The mean contents of IL-17, IL-21 and IL-23 were 164.71 ±39.37 pg/mL, 199±97.86 pg/mL and 78.94±26.33 pg/mL, respectively, in the AR patients, and 67.75±18.24 pg/mL, 7.58±5.49 pg/mL and 13.58± 3.93 pg/mL, respectively, in the healthy subjects. Statistical analysis showed the serum levels of IL-17 and IL-23 in the AR patients were markedly higher than those in the healthy subjects, however, no significant difference was noted in the content of IL-21. Furthermore, the IL-17 level was positively related to the levels of IL-23 and IgE and the IL-23 level was positively related to the IgE level among AR patients, but no relations were observed between the IL-21 level and levels of IL-17, IL-23 and IgE. Our study indicates IL-17 and IL-23 may play an important role in the pathogenesis of AR and maybe IL-21 is not involved in the occurrence of AR. Cilj ove studije bio je da se utvrdi ekspresija interleukina-17 (IL-17), IL-21 i IL-23 u serumu pacijenata sa alergijskim rinitisom (AR) kao i da se ispita njihov odnos sa specifičnim IgE u serumu. Obuhvaćeni su pacijenti sa AR (n=24) i zdravi ispitanici (n=12) od kojih su uzeti uzorci seruma. Nivo IgE specifičnog za inhalatorne alergene u serumu određen je pomoću sistema za automatsku kvantitativnu imunofluorescentnu analizu, dok su količine IL-17, IL-21 i IL-23 u serumu utvrđene pomoću ELISA. Nivo IgE u serumu zdravih osoba obeležen je kao nulti stupanj a kod pacijenata sa AR stupnjevima od 2 do 6. Srednje vrednosti IL-17, IL-21 i IL-23 bile su 164,71±39,37 pg/mL, 199±97,86 pg/mL i 78,94±26,33 pg/mL kod pacijenata sa AR, i 67,75±18,24 pg/mL, 7,58±5,49 pg/mL i 13,58±3,93 pg/mL kod zdravih ispitanika. Statistička analiza pokazala je da su nivoi IL-17 i IL-23 u serumu pacijenata sa AR bili značajno viši nego kod zdravih ispitanika, dok za vrednosti IL-21 nije uočena značajna razlika. Štaviše, nivo IL-17 pokazao je pozitivnost u odnosu sa nivoima IL-23 i IgE, dok je nivo IL-23 imao pozitivan odnos sa nivoom IgE kod pacijenata sa AR, ali nije utvrđena povezanost između nivoa IL-21 i nivoa IL-17, IL-23 i IgE. Naša studija ukazuje na potencijalno važnu ulogu IL-17 i IL-23 u patogenezi AR, dok IL-21 možda ne učestvuje u nastanku AR.