Contaminants in water pose a significant challenge as they are harmful and difficult to treat using conventional methods. Therefore, various new methods have been proposed to degrade organic pollutants in water, among which the photo-Fenton process is considered promising. In recent years, Fe-based metal-organic frameworks (Fe-MOFs) have gained attention and found applications in different fields due to their cost-effectiveness, non-toxic nature, and unique porous structure. Many researchers have applied Fe-MOFs to the photo-Fenton process in recent years and achieved good results. This review focuses on describing different strategies for enhancing the performance of Fe-MOFs in the photo-Fenton process. Also, the mechanism of MOF in the photo-Fenton process is described in detail. Finally, prospects for the application of Fe-MOFs in photo-Fenton systems for the treatment of organic pollutants in water are presented. This study provides information and ideas for researchers to use Fe-MOFs to remove organic pollutants from water by photo-Fenton process. Display omitted •Various enhancement methods of Fe-MOF in photo-Fenton process are described.•Catalytic mechanism of Fe-MOFs in photo Fenton process was discussed.•Potential application prospects and challenges of Fe-MOFs in photo Fenton process prospect.