Liposome Enhanced Detection of Amyloid Protein Aggregates

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Liposome Enhanced Detection of Amyloid Protein Aggregates

Kocsis, Istvan; Sanna, Elena; Hunter, Christopher A

Organic letters, 02/2021, Volume: 23, Issue: 3

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Thioflavin-T is used to image amyloid aggregates because of the excellent turn-on fluorescence properties, but binding affinities are low. By mounting multiple dye units on the surface of a vesicle, the binding affinity for α-synuclein fibrils is increased by three orders of magnitude, and the optical response is increased. Cooperative interactions of the dye headgroup and lipid with the protein provide a general strategy for the construction of multivalent amyloid probes based on vesicles.

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Kocsis, Istvan | Sanna, Elena | Hunter, Christopher A

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