InFlamiN’ the brain in Alzheimer’s disease

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InFlamiN’ the brain in Alzheimer’s disease

Neher, Jonas J.

Immunity (Cambridge, Mass.), 05/2022, Volume: 55, Issue: 5

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Although consistently implicated, the exact role of interferon (IFN) signaling in Alzheimer’s disease remains largely unexplored. Roy et al. now demonstrate that type I IFNs may drive cognitive dysfunction through acting not only on microglia but, surprisingly, also on neurons. Although consistently implicated, the exact role of interferon (IFN) signaling in Alzheimer’s disease remains largely unexplored. Roy et al. now demonstrate that type I IFNs may drive cognitive dysfunction through acting not only on microglia but, surprisingly, also on neurons.

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