Nursing homes are designed and operated to meet general thermal specifications outlined by existing standards. This paper presents adaptive thermal comfort models for nursing homes based on the field survey administered in 100 common rooms of five nursing homes in the Mediterranean climate. The survey included simultaneous measurements of outdoor and indoor environmental parameters and an assessment of the occupants’ thermal comfort sensations using questionnaires. In total, 1,921 subjective questionnaires were obtained. The analysis focused on: Building Operation Mode (naturally ventilated and air-conditioned mode (cooling and heating)); and type of occupant (residents and non-residents (caregivers and therapists)). In naturally ventilated rooms residents were found to be more adaptive than what EN and ASHRAE 55:2020 standards propose (Tc (naturally ventilated) = 0.26 Trm + 18.83 (R2 = 0.81)). Residents in air-conditioned rooms were found to be less sensitive to outdoor conditions (Tc (air-conditioned) = 0.16Trm + 20.41 (R2 = 0,91)) than in naturally ventilated rooms. Both adaptive thermal models fall in limits set by these standards but in the lower acceptable levels. These adaptive thermal comfort models for nursing homes will allow extending the use of natural ventilation and the adoption of setpoint temperatures when air-conditioning is needed with the consequent reduction of heating and cooling use.