E-resources
-
Nakatochi, Masahiro; Kanai, Masahiro; Nakayama, Akiyoshi; Hishida, Asahi; Kawamura, Yusuke; Ichihara, Sahoko; Akiyama, Masato; Ikezaki, Hiroaki; Furusyo, Norihiro; Shimizu, Seiko; Yamamoto, Ken; Hirata, Makoto; Okada, Rieko; Kawai, Sayo; Kawaguchi, Makoto; Nishida, Yuichiro; Shimanoe, Chisato; Ibusuki, Rie; Takezaki, Toshiro; Nakajima, Mayuko; Takao, Mikiya; Ozaki, Etsuko; Matsui, Daisuke; Nishiyama, Takeshi; Suzuki, Sadao; Takashima, Naoyuki; Kita, Yoshikuni; Endoh, Kaori; Kuriki, Kiyonori; Uemura, Hirokazu; Arisawa, Kokichi; Oze, Isao; Matsuo, Keitaro; Nakamura, Yohko; Mikami, Haruo; Tamura, Takashi; Nakashima, Hiroshi; Nakamura, Takahiro; Kato, Norihiro; Matsuda, Koichi; Murakami, Yoshinori; Matsubara, Tatsuaki; Naito, Mariko; Kubo, Michiaki; Kamatani, Yoichiro; Shinomiya, Nariyoshi; Yokota, Mitsuhiro; Wakai, Kenji; Okada, Yukinori; Matsuo, Hirotaka
Communications biology, 04/2019, Volume: 2, Issue: 1Journal Article
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci ( <5 × 10 ) including eight novel loci. Of these, missense variants of and were predicted to be damaging to the function of these proteins; another five loci- , , , , and -are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, , is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.