Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation

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Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation

Sidi, Samuel; Bouchier-Hayes, Lisa

Molecular & cellular oncology, 09/2017, Volume: 4, Issue: 5

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Despite being frequently mutated or deregulated in acute myeloid leukemia (AML) and many other cancers, the mechanisms by which nucleophosmin (NPM1) regulates oncogenesis remain elusive. We found that NPM1 plays a direct and conserved role in DNA damage-induced assembly of the PIDDosome complex, the activating platform for caspase-2. This function is carried in the nucleolus and is essential for caspase-2-mediated apoptosis in response to a variety of DNA injuries.

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Sidi, Samuel | Bouchier-Hayes, Lisa

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